Part 2: How to Repair Excel 2016 Files on Mac? There can be issues regarding data entry and processing of other inbuilt tools. Other issues: Sometimes, users can encounter issues while saving an Excel file.Excel 2016 Runtime Error: The application might not have loaded properly, or it has been corrupted.Formula errors in Excel 2016: You could have entered a wrong formula or Excel is not able to detect it properly.Excel 2016 has stopped working: There might not be enough free space on the system, or the application has entered a deadlock.